Technical Data
O7030-39E
OPRM1 (Mu Opioid Receptor, Mu-type Opioid Receptor, M-OR-1, MOR-1, Mu Opiate Receptor, Mu Opioid Receptor, MOP, hMOP, MOR1)
Description:
G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that activate intracellular signaling cascades and undergo endocytosis, recycling, or degradation upon stimulation. The mu, delta and kappa opioid receptors are GPCRs of the nervous system, which control pain, stress, and addictive behaviors. The mu opioid receptor (MOR-1) is a high-affinity receptor for enkephalins and beta-endorphins with low affinity for dynorphins. The opiate alkaloids morphine and codeine bind to MOR-1.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.

Positive Control:
Human, mouse and rat brain lysate

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
1mg-20CBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
Synthetic peptide corresponding to aa386-400 NHQLENLEAETAPLP of the human, mouse and rat MOR-1 protein.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity:
Recognizes human MOR-1. Species Crossreactivity: mouse and rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Wang, J.B., Johnson, P.S., Persico, A.M., Hawkins, A.L., Griffin, C.A. and Uhl, G.R. Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Lett. 338(2), 217-222 (1994). 2. Mestek, A., Hurley, J.H., Bye, L.S., Campbell, A.D., Chen, Y., Tian, M., Liu,J., Schulman,H. and Yu,L. The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C. J. Neurosci. 15(3 PT 2), 2396-2406 (1995).