Technical Data
P3342-20D
Period Clock Protein 2 (Period 2, Period-2, Period 2 Isoform 1, Period Circadian Protein 2, Period Circadian Protein Homolog 2, Period Homolog 2, PER2, Circadian Clock Protein PERIOD2, Circadian Clock Protein PERIOD-2, FASPS, hPER2, KIAA0347)
Description:
PER2, a mammalian homolog of the Drosphilia period gene, shares 40% homology with PER1 including the protein dimerization PAS domain. A strong circadian rhythmic expression in the suprachiasmatic nuclei supports the view that the mammalian PER gene functions in the circadian clock with PER2 being a component of the circadian oscillator.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ul4C (-20C Glycerol)Blue IceHumanRabbit
Concentration:
Not determined
Immunogen:
Two peptides derived from human PER2. Antibodies crossreacting with each peptide were affinity purified against the appropriate peptide.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.4.
Specificity:
Recognizes human PER2. Species Sequence Homology: Peptide 1 shows significant homology to rat (94.4%). Peptide 2 shows significant homology to rat and mouse (94.4%).
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Shearman, L.P., et al., Neuron 19: 1261-1269 (1997). 2. Zheng, B., et al., Nature 400: 169-173 (1999). 3. Takumi, T., et al., Genes Cells. 3: 167-176 (1998). 4. Shearman, L.P. and Weaver, D.R., Neuroreport. 10: 613-618 (1999).