Technical Data
Peripherin (PRPH, Neurofilament 4, NEF4)
Peripherin is a 57kD Class III intermediate filament subunit found initially in sensory neurons of the peripheral nervous system, which gives the protein its name. Certain sensory neurons in the brain stem express Peripherin normally, as do a few cortical and hippocampal neurons. Interestingly, peripherin protein is upregulated in the lower motor neurons that degenerate in Amyotrophic Lateral Sclerosis (ALS), focusing attention on peripherin as a potential contributory factor to this serious human neurodegenerative disease. Peripherin is also expressed in certain neuroendocrine tumors and in the insulinproducing cells of the pancreas.

Suitable for use in Immunofluorescence and Western Blot. Other applications not tested.

Recommended Dilution:
Immunofluorescence: 1:500
Western Blot: 1:2500
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
MabIgG8A240Affinity Purified
100ug-20CBlue IceRatMouse
Recombinant rat peripherin purified from E. coli
Purified by immunoaffinity chromatography.
Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
Recognizes rat Peripherin Species crossreactivity: human, rabbit, feline and mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Keilhauer CN, et al. Clinical Findings in a Multigeneration Family With Autosomal Dominant Central Areolar Choroidal Dystrophy Associated With an Arg195Leu Mutation in the Peripherin/RDS Gene. Arch. Ophthalmol. Jul 2006; 124(7): 1020-1027. 2. Lee ES, et al. Characterization of peripherin/rds and rom-1 transport in rod photoreceptors of transgenic and knockout animals. Invest. Ophthalmol. Vis. Sci. May 2006; 47(5): 2150-2160.