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Technical Data |
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P4072-06B1 |
Phosphodiesterase 6 beta (Phosphodiesterase 6B, Phosphodiesterase 6B cGMP-specific Rod beta, PDE6 beta, PDE6B, Congenital Stationary Night Blindness 3 Autosomal Dominant, CSNB3, Dunce-like Phosphodiesterase 4, DPDE4, GMP-PDE beta, PDEB, Rd1, Rod cGMP-spec |
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Description: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding difference isoforms have been found for this gene. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2ug/ml Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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