Technical Data
P6000-04
Prealbumin (PALB, Amyloid Polyneuropathy, Amyloidosis I, ATTR, Dysprealbuminemic Euthyroidal Hyperthyroxinemia, Dystransthyretinemic Hyperthyroxinemia, HsT2651, Prealbumin Amyloidosis Type I, Senile Systemic Amyloidosis, TBPA, Transthyretin, TTR, TTR Prot
Description:
Prealbumin (TTR) is a hormone-binding protein that participates in the plasma transport of both thyroxine and retinol (vitamin A). Prealbumin concentrations are disproportionately high in human ventricular cerebrospinal fluid (CSF). It is reported to be either selectively transported across or synthesized within the blood-CSF barrier (3). Over 80 different disease-causing mutations in prealbumin have been reported. The vast majority is inherited in an autosomal dominant manner and is related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. A small portion of prealbumin mutations are apparently non-amyloidogenic (4). The human amyloid disorders, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and senile systemic amyloidosis, are caused by insoluble prealbumin fibrils (2).

Applications:
Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation and Flow Cytometry. Other applications not tested.

Recommended Dilution:
Western Blot: 1:2500-1:5000
Immunohistochemistry: 1:250-1:500
Immunocytochemistry: 1:100
Immunoprecipitation: 1:60
Flow Cytometry: 1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 

Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
TypeIsotypeCloneGrade
MabIgG9E462Supernatant
SizeStorageShippingSourceHost
100ul-20°CBlue IceHumanRabbit
Concentration:
Not Determined
Immunogen:
Synthetic peptide corresponding to residues on the C-terminus of human Prealbumin.
Purity:
Supernatant
Form
Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.01% sodium azide, 0.05% BSA, 40% glycerol.
Specificity:
Recognizes human Prealbumin at ~16kD.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Klabunde T, et al. Nat Struct Biol. 7(4):312-21, 2000. 2. Herbert J, et al. Neurology 36(7):900-11, 1986. 3. Saraiva MJ Hum Mutat. 17(6):493-503, 2001.