Technical Data
Q1101
Quinomycin A (Echinomycin, Actinoleukin, Antibiotic 1491, Antibiotic 59266, Antibiotic X 948, Antibiotic X 53III)
1mg
Biochemicals Storage: -20CShipping: Blue Ice
Quiniomycin A is a cyclic depsipeptide metabolite. It has broad activity against bacteria, fungi and viruses and has found application as an antitumor agent. Quinomycin A acts by bifunctional intercalation of nucleic acids. Recent research has shown quinomycin A to be an extremely potent inhibitor of Hypoxia-inducible factor-1 (HIF-1). This transcription factor plays an essential role in tumor progression and metastasis. Related to: Qunaldopeptin

Solubility:
Soluble in ethanol, methanol, DMF or DMSO.

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

CAS Number:
512-64-1

Molecular Formula:
C51H64N12O12S2

Molecular Weight:
1101.3
Source: Streptomyces sp.
Purity: 99% by HPLC
Form: Supplied as a white solid.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Serendipitous SAD phasing of an echinomycin-(ACGTACGT)2 bisintercalation complex. Cuesta-Seijo J.A. et al. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 417. 2. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Kong D. et al. Cancer Res. 2005, 65, 9047. 3. Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway. Park J.Y. et al. Pharmacol. Res. 2004, 50, 201.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.