Technical Data
R0009-82B
Rab24 (Ras-related Protein Rab-24)
Description:
Rab24 is an atypical member of the Rab GTPase family involved in the regulation of macroautophagy and the degradation of misfolded proteins or nucleocytoplasmic transport. Unlike other members of the family, the protein appears to have a very low intrinsic GTPase activity. Furthermore, Rab24 is not efficiently geranylgeranylated and does not form a detectable complex with a carrier protein, guanine nucleotide dissociation inhibitor (GDI). Northern blot analyses confirm the ubiquitous expression of the protein in human tissues, with the mRNA being most abundant in heart, pancreas and peripheral blood leukocytes, with comparatively low expression in brain. The expression of Rab24 mRNA in peripheral blood mononucleated cells is induced in patients with tuberculosis. The gene encoding for human Rab24 is localized on chromosome 5q35.3.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanRabbit
Concentration:
Not determined.
Immunogen:
Synthetic peptide corresponding to aa177-194 ([BLAST]AFQVMTEDKGVDLGQKPN[BLAST]) of human Rab24.
Purity:
Serum
Form
Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Specificity:
Recognizes human Rab24. Species Crossreactivity: chimpanzee and monkey. Species sequence homology: mouse, canine, zebrafish, xenopus, chicken.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Erdman, RA. et al. J. Biol. Chem. 275:3848-3856 (2000). 2. Maltese, WA. et al. BMC. Cell. Biol. 3:25-41 (2002).