Technical Data
Rabies virus is a Lyssavirus that causes rabies in mammals. The virus is found in the saliva of infected animals and is mostly spread though bites. The virus then travels though the peripheral nervous system to the central nervous system. Once it reaches the brain it causes acute encephalitis. Symptoms include paralysis, cerebral dysfunction, anxiety, insomnia, confusion, anger, paranoia, terror and hallucination. The production of a large amount of saliva, the inability to speak or swallow and associated hydrophobia is also common in the later stages of the disease. The time between exposure to the virus and onset of symptoms can range from about 2 weeks to several months. Once symptoms appear, death is virtually inevitable. However, the disease can be effectively treated by post-exposure prophylaxis, through vaccination, provided this is done as soon as possible.

Suitable for use in Immunofluorescence, Indirect ELISA and Immunohistochemistry. Other applications not tested.

Recommended Dilutions:
Immunohistochemistry: Formalin-fixed paraffin embedded sections.
Optimal dilutions to be determined by the researcher.

Immunofluorescence: >1x10e3 (Titer by Native BHK)
Indirect ELISA: 1.5x10e6 (Titer by Indirect ELISA)

Sp2/0 myeloma cells with spleen cells from Balb/c mice.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
MabIgG2a1.B.456Affinity Purified
1mg-20CBlue IceMouse
Purified rabies virus
Purified by Protein G chromatography.
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Recognizes a glycoprotein of more than 20 different strains of rabies virus from 4 serogroups: CVS, Lagosbat, Mokola, Duwenhage were positive in neutralization reaction.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Macikova, I., et al., Common and different antigenic properties of the rabies virus glycoprotein of strains SAD-Vnukovo and Pitman-Moore. Acta. Virol. 36(6): 541-550 (1992).
2. Drew WL (2004). "Chapter 41: Rabies". In Ryan KJ, Ray CG (editors). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 597600. ISBN 0-8385-8529-9.
3. Finke S, Conzelmann KK (August 2005). "Replication strategies of rabies virus". Virus Res. 111 (2): 12031. doi:10.1016/j.virusres.2005.04.004. PMID 15885837.