Technical Data
Serotonin Receptor 4 (5-Hydroxytryptamine 4 Receptor, 5-Hydroxytryptamine-4 Receptor, 5-HT4R, 5-Hydroxytryptamine Receptor 4, 5-Hydroxytryptamine Serotonin Receptor 4, 5HT4, 5-HT-4, 5-HT4, Cardiac 5-HT4 Receptor, HTR4, Serotonin 5-HT4 Receptor)
The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14 amino acids into the second intracellular loop. 5-HT4 receptor expression has been documented primarily in the brain, and in colon, heart, and vessel. An EST has been isolated from a human cancerous nerve library.

Suitable for use in Immunohistochemistry (paraffin-embedded sections). Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabAffinity Purified
50ul-20CBlue IceHumanRabbit
3rd cytoplasmic domain of human.
Purified by immunoaffinity chromatography.
Supplied as a liquid in PBS, pH 7.2.
Species Crossreactivity: Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.