Technical Data
Sodium Butyrate, 1M (Histone Deacetylase Inhibitor)
Biochemicals Storage: 4°CShipping: Blue Ice
A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells.

For use as a histone deacetylase inhibitor.

Recommended Dilutions:
1, 5, 20 and 100mM showed >70% inhibition of HDAC activity in HeLa nuclear extract using H5109-62: Histone Deacetylase (HDAC), BioAssay™ Fluorometric Detection Kit.
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Store at 4°C. Stable for 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Formula:

Molecular Weight:
Purity: 90-100%
Form: Supplied as a liquid in 1M solution in sterile distilled water.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Miyashuta et al., FEBS Lett. 353:225-229, 1994, Ohno et al., PNAS, 94:10279-10284, 1997.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.