Technical Data
S5558
Splitomicin (Splitomycin)
5mg
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Technical Data |
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S5558 |
Splitomicin (Splitomycin) |
5mg |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
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Potent inhibitor of yeast NAD+-dependent histone deacetylase Sir2p (IC50 = 60uM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering ot blocking access to the acetylated histone binding pocket. Applications: Suitable for use as a histone deacetylase inhibitor. Other applications have not been tested Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with DMSO. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. CAS Number: 5690-03-9 Molecular Formula: C13H10O2 Molecular Weight: 198.2 |
Purity: 98% Form: Supplied as a white to off-white solid. Soluble in DMSO. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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