Technical Data
Splitomicin (Splitomycin)
Biochemicals Storage: -20CShipping: Blue Ice
Potent inhibitor of yeast NAD+-dependent histone deacetylase Sir2p (IC50 = 60uM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering ot blocking access to the acetylated histone binding pocket.

Suitable for use as a histone deacetylase inhibitor. Other applications have not been tested

Recommended Dilutions:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Lyophilized powder may be stored at -20C. Reconstitute with DMSO. Aliquot and store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from light and moisture.

CAS Number:

Molecular Formula:

Molecular Weight:
Purity: 98%
Form: Supplied as a white to off-white solid. Soluble in DMSO.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Bedalov A et. al., Proc. Natl. Acad. SCi. USA 98: 15113 (2001)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.