Technical Data
S8000-02B
Substance P (NK, Neurokinin)
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Technical Data |
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S8000-02B |
Substance P (NK, Neurokinin) |
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Description: Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. Substance P containing nerve fibers in the gut wall are particularly numerous in the myenteric plexus and the smooth muscle layers. Substance P containing tumors arising in the ileum are often associated with the “carcinoid syndrome,” are characterized by flushing of the skin, diarrhea, bronchoconstriction and sudden drops in blood pressure. Substance P is commonly found in midgut carcinoids and some of the symptoms may be related to this peptide. This antibody can be used for the diagnosis of ileum carcinoids. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Frozen): 1:50 using the Indirect Method. Dilute immediately before use with PBS or Tris. Optimal dilutions to be determined by the researcher. Positive control: Spinal cord (dorsal horn), colon Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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