Technical Data
S8000-02B
Substance P (NK, Neurokinin)
Description:
Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. Substance P containing nerve fibers in the gut wall are particularly numerous in the myenteric plexus and the smooth muscle layers. Substance P containing tumors arising in the ileum are often associated with the “carcinoid syndrome,” are characterized by flushing of the skin, diarrhea, bronchoconstriction and sudden drops in blood pressure. Substance P is commonly found in midgut carcinoids and some of the symptoms may be related to this peptide. This antibody can be used for the diagnosis of ileum carcinoids.

Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (Frozen): 1:50 using the Indirect Method. Dilute immediately before use with PBS or Tris.
Optimal dilutions to be determined by the researcher.

Positive control:
Spinal cord (dorsal horn), colon

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabSerum
SizeStorageShippingSourceHost
250ul-20°CBlue IceRabbit
Concentration:
Not determined
Immunogen:
Synthetic Substance P (KLH)
Purity:
Serum
Form
Supplied as a liquid.
Specificity:
Recognizes Substance P. Species Crossreactivity: Human, rat
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Dixon,J.S. et al J.Anat. 192 (1988) 407-415.