Technical Data
Substance P (NK, Neurokinin)
Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. Substance P containing nerve fibers in the gut wall are particularly numerous in the myenteric plexus and the smooth muscle layers. Substance P containing tumors arising in the ileum are often associated with the “carcinoid syndrome,” are characterized by flushing of the skin, diarrhea, bronchoconstriction and sudden drops in blood pressure. Substance P is commonly found in midgut carcinoids and some of the symptoms may be related to this peptide. This antibody can be used for the diagnosis of ileum carcinoids.

Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (Frozen): 1:50 using the Indirect Method. Dilute immediately before use with PBS or Tris.
Optimal dilutions to be determined by the researcher.

Positive control:
Spinal cord (dorsal horn), colon

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
250ul-20°CBlue IceRabbit
Not determined
Synthetic Substance P (KLH)
Supplied as a liquid.
Recognizes Substance P. Species Crossreactivity: Human, rat
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Dixon,J.S. et al J.Anat. 192 (1988) 407-415.