Technical Data
Substance P (NK, Neurokinin)
The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.

Application(s): 1:1001:200 by immunohistochemistry on human brain.
100ul-20CBlue IceHumanRat
Not determined
Substance P conjugated to BSA
Tissue culture supernatant.
Supplied as a liquid containing 0.01% thimerosal.
Reacts with COOH-terminal end of Substance P. No crossreactivity to Leu-or Metenkephalin, somatostatin or beta-endorphin. Eledoisin 5% Species Reactivity: Animal and human.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Cuello, A.C., Glafre, G., Milstein, C. (1979) Detection of Substance P in the central nervous system by a monoclonal antibody. Proc. Natl. Acad. USA, 76:35323536. 2. Cuello, A.C., Milstein, C., and Priestly, J. V. (1980). Use of monoclonal antibodies in immunocytochemistry with special reference to the central nervous system. Brain Res. Bull. 5:575587. 3. Cuello A.C. (1981). Monoclonal antibodies in neuroanatomical research. In: Cytochemical methods in neuroanatomy, V. Cahnpalay and S.L. Palay (Eds.). 4. Cuello, A.C., Priestly, J.V., and Matthews, M.R. (1982): Localisation of Substance P in neuronal pathways. In the nervous system, Pitman, London. (Ciba Foundation Sysposium 91) 5583. 5. Pioro, E.P., Hughes, J.T. and Cuello, A.C. (1985). Loss of Substance P immunoractivity in the nucleus of the spinal trigeminal tract after