Technical Data
Synuclein, alpha
Synuclein-alpha is the major component of Lewy bodies and Lewy neuritis in sporadic PD. dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20kDa) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma-synuclein and synoretin. The expression is abundant in neurons and typically localized at presynaptic terminals.

Source: Tissue culture supernatant

Applications: Suitable for use in Western/Dot Blot, ELISA, Immunohistochemistry (Frozen and formalin-fixed paraffin-embedded tissues. No formic acid, enzyme or HIER required).

Recommended Dilution: Optimal dilutions to be determined by the researcher.

Storage and Stability: May be stored at 4įC for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20įC. Aliquots are stable for at least 12 months at -20įC. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
MabIgG12B84Highly Purified
100ul-20įCBlue IceHumanMouse
Not determined
Purified E. coli produced human alpha-synuclein
Purified by ammonium sulfate precipitation.
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
Recognizes human alpha-synuclein.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
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