Technical Data
T5348-98Y
Thyroid Hormone Receptor, alpha (THRa)
Description:
Thyroid hormones regulate general metabolism and normal cellular growth and development. These actions are regulated by the thyroid hormone receptor (TR), a ligand-dependent transcriptional factor. At least two genes and several isoforms encode TR. Recent studies have implicated a role of TRs in thyroid hormone-induced apoptosis in larval tissues and proliferation of adult cell types.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:2000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceZebrafishGoat
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to C-QEGSTGVAAQED, from the C Terminus of Thra (NP_571471.1).
Purity:
Purified by affinity chromatography.
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
Specificity:
Recognizes Thyroid Hormone Receptor, alpha. Species Sequence homology: zebrafish.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Jones I, Rogers SA, Kille P, Sweeney GE. Molecular cloning and expression of thyroid hormone receptor alpha during salmonid development. Gen Comp Endocrinol. 2002 Feb 1;125(2):226-35.