		Technical Data
T8171-96A	TRAF2 Binding Protein (TRAF2-binding Protein, T2BP, Putative MAPK-activating Protein PM14, Putative NF-kappa-B-activating Protein 20, TRAF-interacting Protein with Forkhead-associated Domain, TRAF-interacting Protein with FHA Domain-containing Protein A,

Description:
T2BP, a novel 184aa protein, is human homolog of mouse Tifa. It consists of a central phosphopeptide-binding FHA domain and a C-terminal TRAF6-binding motif. T2BP mediates multiple protein-protein interactions and plays a significant role in innate immunity, adaptive immunity and inflammation. It interacts with TRAF2 and is involved in TNF-mediated signaling. It induces oligomerization and polyubiquitination of TRAF6 leading to activation of TAK1 and IKK in a proteasome-independent mechanism and mediates NF-kappaB and JNK activation. It enhances IRAK1/TRAF6 interactions and mediates IL-1 signaling suggesting a novel regulation of innate immunity and inflammation.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Serum

Size		Storage	Shipping	Source	Host
100ul		-20°C	Blue Ice	Human	Rabbit

Concentration:

Not determined.

Immunogen:

Synthetic peptide corresponding to aa150-162 of human T2BP, TIFA.

Purity:

Serum

Form

Supplied as a liquid.

Specificity:

Recognizes human TRAF2 Binding Protein.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Kanamori et.al Biochem Biophys Res Commun.,290(3):1108-13 (2002 Jan 25) 2. Hiroshi et.al J. Biol. Chem., 278 (14); 12144-12150 (April 4, 2003) 3. Ea et.al PNAS 101 (43); 15318-15323 (October 26, 2004).