Technical Data
Transforming Growth Factor beta Receptor I (TGF beta Receptor I, TbetaR-I, TGF beta Receptor Type 1, TGF beta Type I Receptor, TGFBR1, TGFR1, TGFR-1, AAT5, Activin A Receptor Type II-like Kinase 53kDa, Activin Receptor-like Kinase 5, ALK5, ALK-5, ACVRLK4,
Transforming growth factor beta (TGFB) inhibits cell proliferation and stimulates cell differentiation. This is achieved through a receptor complex of types I and II TGFB receptors. The type II receptor is a transmembrane serine/threonine kinase which is able to bind TGFB and transactivate the type I receptor. TGFB receptors are found in all myometrial tissues and, in the kidney, they are found exclusively in renal tubular cells. In normal gastric mucosa, type I and II receptors are demonstrated in fundic glands, but not on surface mucous cells and in normal small bowel and colon, TGFB receptors are expressed in the epithelial cells of the upper crypts.

Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilutions:
Immunohistochemistry (Paraffin): 1:25-1:50 Tryptic digestion of paraffin sections may enhance staining in some cases. Primary antibody incubation: 1hr at RT. Standard ABC technique for detection.
Immunohistochemistry: 1:10-1:2000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
50ul-20CBlue IceHumanMouse
Not Determined
Prokaryotic recombinant protein corresponding to the external domain of the human transforming growth factor beta receptor type 1 molecule.
Supplied as a liquid, 15mM sodium azide.
Recognizes human Transforming Growth Factor beta Receptor I.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.