Technical Data
T9156-65
Tubulin Polymerization Promoting Protein (TPPP, TPPP/p25, TPPP 1, TPPP1, 25kD Brain-specific Protein, Brain-specific Protein p25 alpha, Glycogen Synthase Kinase 3 (GSK3) Inhibitor p24, p24, p25, p25alpha)
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Technical Data |
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T9156-65 |
Tubulin Polymerization Promoting Protein (TPPP, TPPP/p25, TPPP 1, TPPP1, 25kD Brain-specific Protein, Brain-specific Protein p25 alpha, Glycogen Synthase Kinase 3 (GSK3) Inhibitor p24, p24, p25, p25alpha) |
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Description: Tubulin polymerization-promoting protein (TPPP) is an unfolded brain-specific protein that interacts with the tubulin/microtubule system, and is enriched in human pathological brain inclusions (1).TPPP can induce aggregation of alpha-synuclein, and can accumulate in oligodendroglial cell bodies containing fibrillized alpha- synuclein multiple system atrophy (MSA), a neurodegenerative disease.TPPP is a constituent of myelin and a high-affinity ligand for myelin basic protein (MBP), and has been shown to colocalize with MBP in myelin in normal human brains (2). Applications: Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50 Western Blot: 1:500-1:1000 Immunohistochemistry: 1:250-1:500 Immunocytochemistry: 1:100-1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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