Technical Data
Vanilloid Receptor Like Protein 3 (Vanilloid Receptor-like 3, VRL 3, VRL-3, VRL3, HGNC:18084, Transient Receptor Potential Cation Channel Subfamily V Member 3, Trpv3 Heat Sensitive Channel, TRPV3)
Vanilloid Receptor-like 3 (VRL-3), also known as transient receptor potential cation channel subfamily V3 (TRPV3) is a 70kD member of the vanilloid receptor/TRP gene family. It is expressed on keratinocytes and neurons, and is physiologically responsive to changes in temperature between 22 C and 40C. Human TRPV3 is 790 amino acids (aa) in length. It is a 6 transmembrane domain protein that contains an N- and C-terminal cytoplasmic region. Three ankyrin repeats occur in the extended N-terminal cytoplasmic region (aa214-369). There is one alternate splice form that shows a 6aa substituton for the C-terminal 31 amino acids. Over amino acids 6-15, human TRPV3 shares 90% aa sequence identity with mouse and canine TRPV3.

Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.

Recommended Dilutions:
Immunohistochemistry: 5-15ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabIgGAffinity Purified
100ug-20CBlue IceHumanSheep
~0.2mg/ml (after reconstitution)
Synthetic peptide corresponding to aa6-15 of human Vanilloid Receptor-like 3, conjugated to KLH (Q8NET8). Species Sequence Homology: mouse and canine, 90%
Purified by affinity chromatography.
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
Recognizes human Vanilloid Receptor-like 3.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.