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G3900-21 Rabbit Anti-GLUT 3 (Glucose Transporter, Insulin Regulatable) (Not for Export EU)

Specifications
Clone Type
Polyclonal
Host
Rabbit
Source
Mouse
Swiss Prot
P32037
Isotype
IgG
Grade
Serum
Applications
E WB
Crossreactivity
Mo Rt
Accession #
NP_035531.3
Shipping Temp
Blue Ice
Storage Temp
-20°C

Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters. Molecular cloning of these glucose transporters has identified a family of closely related genes that encodes at least 7 proteins (GLUT 1 to GLUT 7, MW 40-60kD) and Sodium glucose co-transporter-1 (SGLT-1, 662aa; ~75kD). Individual members of this family have identical predicted secondary structures with 12 transmembrane domains. Both N- and C-termini are predicted to be cytoplasmic. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue-specific targeting. GLUT isoforms differ in their tissue expression, substrate specificity and kinetic characteristics. GLUT 1 mediates glucose transport into red cells, and throughout the blood brain barrier, and supply glucose to most cells. GLUT 2 provides glucose to the liver and pancreatic cells. GLUT 3 is the main transporter in neurons, whereas GLUT 4 is primarily expressed in muscle and adipose tissue and regulated by insulin.

Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilution
Western Blot: 1:1000-1:5000 (ECL) ELISA: 1:10,000–1:50,000, using 50–100ng of antigen/well. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to the C-terminus, aa481-483, NSMQPVKETPGNA of mouse Glut-3 (KLH).
Form
Supplied as a liquid, 0.05% sodium azide
Purity
Serum
Specificity
Recognizes mouse Glut-3. Species Crossreactivity: rat. Does not recognize human.
Conjugates
Pricing
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