Crossveinless-2 (CV-2), also known as BMPER2 (BMP-binding endothelial regulator), is a secreted glycoprotein that contains a trypsin-inhibitory like domain, five cysteine-rich domains, and a von Willebrand factor type D domain. CV-2 modulates the activity of BMP-2 and BMP-4 in neural crest migration and osteoblast and chondrocyte differentiation. During zebrafish gastrulation, CV-2 is proteolytically cleaved to generate a BMP agonist from a BMP antagonist. Mature human and mouse CV-2 share 93% aa sequence identity.