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030243 Mouse Anti-FOXP2

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
O15409
Isotype
IgG1
Clone Number
13B321
Grade
Ascites
Applications
E WB
Crossreactivity
Hu
Gene ID
93986
Shipping Temp
Blue Ice
Storage Temp
-20°C
SPCH1; CAGH44; TNRC10; DKFZp686H1726

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.

Applications
Western Bloting: 1:500-1:2000. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Purified recombinant fragment of human MAPK3 expressed in E. coli.
Form
Supplied as a liquid, 0.03% sodium azide.
Purity
Ascites
Specificity
Human
References
1. Nature. 2009 Nov 12;462(7270):213-7.|2. Mol Biol Evol. 2009 Oct;26(10):2181-4.
USBio References
No references available
Conjugates
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