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031953 Rabbit Anti-APBA2, ID (APBA2, MINT2, X11L, Amyloid beta A4 precursor protein-binding family A member 2, Adapter protein X11beta, Neuron-specific X11L protein, Neuronal Munc18-1-interacting protein 2)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Mouse
Swiss Prot
Q99767
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Mo
Accession #
NP_005494.2; NP_001123886.1;
Gene ID
321
Gene #
APBA2
Shipping Temp
Blue Ice
Storage Temp
-20°C
APBA2, MINT2, X11L, Amyloid beta A4 precursor protein-binding family A member 2, Adapter protein X11beta, Neuron-specific X11L protein, Neuronal Munc18-1-interacting protein 2

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
APBA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-344 amino acids from the Central region of human APBA2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Mouse
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Swistowski, A., et al. J. Neurosci. 29(50):15703-15712(2009)|Mitchell, J.C., et al. Hum. Mol. Genet. 18(23):4492-4500(2009)|Babatz, T.D., et al. Autism Res 2(6):359-364(2009)|Chang, S.J., et al. BMC Genomics 10, 613 (2009) :
USBio References
No references available
Conjugates
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