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034993 Rabbit Anti-EIF2B4, ID (K161) (EIF2B4, EIF2BD, Translation initiation factor eIF-2B subunit delta, eIF-2B GDP-GTP exchange factor subunit delta)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9UI10
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu Mo
Accession #
NP_001029288
Gene ID
8890
Gene #
EIF2B4
Shipping Temp
Blue Ice
Storage Temp
-20°C

Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Applications
Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000 Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilution determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within 146-175 amino acids from the central region of human EIF2B4. Species sequence homology: bovine
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human EIF2B4. Species Crossreactivity: mouse
References
1. Naukkarinen, J., et al. PLoS Genet. 6(6), E1000976 (2010).|2. Wu, Y., et al. J. Hum. Genet. 54(2):74-77 (2009).|3. Horzinski, L., et al. PLoS ONE 4(12), E8318 (2009).|4. Pronk, J., et al. Mult. Scler. 14(8):1123-1126 (2008).|5. Wong, S.S., et al. J. Child Neurol. 23(6):710-714 (2008).
USBio References
No references available
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