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036930 Rabbit Anti-IHH, NT (IHH, Indian hedgehog protein, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q14623
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu
Accession #
NP_002172.2
Gene ID
3549
Gene #
IHH
Shipping Temp
Blue Ice
Storage Temp
-20°C
IHH, Indian hedgehog protein, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product

This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.

Applications
Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 51-80 in the N-terminal region of human IHH, UniProt Accession #Q14623. Species Sequence Homology: mouse
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human IHH.
References
1. Meulenbelt, I., et al. Ann. Rheum. Dis. (2010). 2. Kang, S.J., et al. Hum. Mol. Genet. 19(13):2725-2738(2010). 3. Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010). 4. Zhao, J., et al. BMC Med. Genet. 11, 96 (2010). 5. Chuang, P.T., et al. Nature 397(6720):617-621(1999)
USBio References
No references available
Conjugates
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