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040836 Rabbit Anti-RARA, CT (RARA, NR1B1, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P10276
Isotype
IgG
Grade
Affinity Purified
Applications
E FC IF IHC WB
Crossreactivity
Hu Mo
Accession #
NP_000955.1
Gene ID
5914
Gene #
RARA
Shipping Temp
Blue Ice
Storage Temp
-20°C
RARA, NR1B1, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.

Applications
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Indirect Flow Cytometry and ELISA. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Immunofluorescence: 1:10-1:50 Indirect Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 322-349 in the C-terminal region of human RARA.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human RARA. Species Crossreactivity: mouse
References
1. Park, U.H., et al. J. Biol. Chem. 285(44):34269-34278(2010) 2. Asleson, A.D., et al. Cancer Genet. Cytogenet. 202(1):33-37(2010) 3. Catalano, A., et al. Blood 110(12):4073-4076(2007) 4. Wells, R.A., et al. Nat. Genet. 17(1):109-113(1997) 5. Chen, Z., et al. Proc. Natl. Acad. Sci. U.S.A. 91(3):1178-1182(1994)
USBio References
No references available
Conjugates
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