Bisindolylmaleimide X hydrochloride

Grade

Highly Purified

Shipping Temp

Storage Temp

4°C/-20°C

Ro 31-8425, BIM X

Selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Inhibits superoxide generation in human neutrophils.

Synonyms

Ro 31-8425; BIM X

CAS Number

131848-97-0 (free base) 145317-11-9

Molecular Weight

461

Molecular Formula

C26H24N4O2•HCl

Solubility

DMSO

Appearance

Supplied as a red solid.

Method for Determining Identity

Proton NMR

Purity

≥95% (HPLC)

Storage and Stability

May be stored at 4°C for short-term only. Stable for 12 months after receipt when stored at -20°C. Store solutions at -20°C in the dark. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

Form

Supplied as a red solid.

Purity

≥95% (HPLC)

References

1. A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli: R.E. Muid, et al.; FEBS Lett. 293, 169 (1991)|2. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)|3. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004)

USBio References

No references available

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044609 Anti-Bisindolylmaleimide X hydrochloride

Grade

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Storage Temp

Ro 31-8425, BIM X

References

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