Ebselen

Grade

Highly Purified

Shipping Temp

Storage Temp

4°C/-20°C

Glutathione peroxidase mimetic. Peroxynitrite scavenger. Anti-inflammatory Antioxidant. Protein kinase C (PKC), NADPH, lipoxygenase, COX, NOS, H+-ATPase and NADPH oxidase inhibitor. Antifungal.

Synonyms

2-Phenyl-1,2-benzisoselenazol-3-(2H)-one

CAS Number

60940-34-3

Molecular Weight

274.2

Molecular Formula

C13H9NOSe

Solubility

DMSO or 100% ethanol

Appearance

Supplied as a white to off-white solid.

Purity

≥98% (HPLC)

Storage and Stability

Short-term storage at 4°C, long-term storage at -20°C. Protect from light. Stable for at least 2 years after receipt when stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

Form

Supplied as a white to off-white solid.

Purity

≥98% (HPLC)

References

1. A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages: M.J. Parnham & S. Kindt; Biochem. Pharmacol. 33, 3247 (1984)|2. Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions: M.J. Parnham & E. Graf; Biochem. Pharmacol. 36, 3095 (1987)|3. Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51): M. Maiorino, et al.; Biochem. Pharmacol. 37, 2267 (1988)|4. Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite: H. Sies & H. Masumoto; Adv. Pharmacol.38, 229 (1997)|5. Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis: Y. Nakamura, et al.; J. Biol. Chem. 277, 2687 (2002)|6. Molecular actions of ebselen-an antiinflammatory antioxidant: T. Schewe; Gen. Pharmacol. 26, 1153 (1995)|7. Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?: I.A. Cotgreave, et al.; Biochem. Pharmacol. 38, 649 (1989)|8. Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione: C. Schewe, et al.; Biochem. Pharmacol. 48, 65 (1994)|9. Evaluation of the antifungal and plasma membrane H+-ATPase inhibitory action of ebselen and two ebselen analogs in S. cerevisiae cultures: B. Billack, et al.; J. Enzyme Inhib. Med. Chem. 25, 312 (2010)|10. Ebselen: a thioredoxin reductase-dependent catalyst for alpha-tocopherol quinone reduction: J. Fang, et al.; Toxicol. Appl. Pharmacol. 207, 103 (2005)