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044791 Anti-Ferutinin (4-Oxy-6-(4-oxybenzoyloxy)dauc-8,9-en, Tefestrol)

Specifications
References
Grade
Highly Purified
Shipping Temp
Blue Ice
Storage Temp
-20°C

Potent, naturally occuring non-steroid estrogenic compound. Tool to promote mitochondrial calcium overload and to promote calcium-dependent opening of the mitochondrial permeability transition pore (mPTP). Strong agonist for estrogen receptor (ER)alpha and agonist/antagonist for ERbeta. Calcium ionophoretic Apoptosis modulator. Antiproliferative. Increases nitric oxide synthase activity and phosphoinositides breakdown in nervous tissue. Shows aphrodisiac and anti-sexual impotence activities. Anti-osteoporotic. Prevents osteoporosis caused by severe estrogen deficiency. Modest AChE inhibitor.

Synonyms
4-Oxy-6-(4-oxybenzoyloxy)dauc-8,9-en; Tefestrol
CAS Number
41743-44-6
Source
Semi-synthetic.
Molecular Formula
C22H30O4
Molecular Weight
358.5
Solubility
DMSO, acetone, dichloromethane or ethyl acetate
Appearance
Supplied as a white to off-white solid.
Purity
≥98% (HPLC)
Storage and Stability
Store at -20°C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Purity
≥98% (HPLC)
Form
Supplied as a white to off-white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Form
Supplied as a white to off-white solid.
Purity
≥98% (HPLC)
References
Product Reference: |●Ionophoretic properties of ferutinin: M.V. Zamaraeva, et al.; Cell Calcium 22, 235 (1997)|●Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta: K. Ikeda, et al.; BBRC 291, 354 (2002)|●Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells: A.Y. Abramov & M.R. Duchen; Cell Calcium 33, 101 (2003)|●Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line: A. Macho, et al.; Biochem. Pharmacol. 68, 875 (2004) |●Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines: F. Poli, et al.; Phytother. Res. 19, 152 (2005)|●Ferutinin stimulates nitric oxide synthase activity in median eminence of the rat: T. Colman-Saizarbitoria, et al.; J. Ethnopharmacol. 106, 327 (2006)|●Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines: R. Alkhatib, et al.; Phytochemistry 69, 2979 (2008)|●The phytoestrogen ferutinin affects female sexual behavior modulating ERalpha expression in the hypothalamus: P. Zanoli, et al.; Behav. Brain Res. 199, 283 (2009)|●Influence of ferutinin on bone metabolism in ovariectomized rats. II: role in recovering osteoporosis: M. Ferretti, et al.; J. Anat. 217, 4 (2010)|●Identification of non-alkaloid acetylcholinesterase inhibitors from Ferulago campestris (Besser) Grecescu (Apiaceae): S. Dall'acqua, et al.; Fitoterapia 81, 1208 (2010)|●Ferutinine structure: A.I. Saidkhodjaev, et al.; Chem. Nat. Comp. 1, 28 (1973)
USBio References
No references available
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