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051934 Goat Anti-IgD (Immunoglobulin D)

Specifications
References
Clone Type
Polyclonal
Host
Goat
Source
Human
Swiss Prot
P01880
Isotype
IgG F(ab’)2
Grade
Purified
Applications
E FC
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

Applications
Suitable for use in ELISA and Flow Cytometry. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Pepsin digest of goat anti-human IgD
Form
Supplied as a liquid in borate buffered saline, pH 8.2.
Purity
Purified
Specificity
Recognizes the heavy chain of human IgD. Has been cross-absorbed against human IgM, IgA and IgG. May react with IgD from other species.
References
1. Xu W, He B, Chiu A, Chadburn A, Shan M, Buldys M, et al. Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI. Nat Immunol. 2007;8:294-303. (IHC-FS, Sep)|2. Xu W, Santini PA, Matthews AJ, Chiu A, Plebani A, He B, et al. Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF. J Immunol. 2008;181:276-87. (IHC-FS)|3. Chen K, Xu W, Wilson M, He B, Miller NW, Bengtén E, et al. Immunoglobulin D enhances immune surveillance by activating antimicrobial, pro-inflammatory and B cell-stimulating programs in basophils. Nat Immunol. 2009;10:889-98. (IHC-FS, IHC-PS, FC)|4. Green LL, Jakobovits A. Regulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes. J Exp Med. 1998;188:483-95. (FC)|5. Joseph AM, Babcock GJ, Thorley-Lawson DA. EBV persistence involves strict selection of latently infected B cells. J Immunol. 2000;165:2975-81. (FC)|6. He B, Xu W, Santini PA, Polydorides AD, Chiu A, Estrella J, et al. Intestinal bacteria trigger T cell-independent immunoglobulin A2 class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity. 2007;26:812-26. (Sep, IHC-FS)|7. Warnatz K, Schlesier M. Flowcytometric phenotyping of common variable immunodeficiency. Cytometry B Clin Cytom. 2008;74:261-71. (FC)|8. He B, Santamaria R, Xu W, Cols M, Chen K, Puga I, et al. The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. Nat Immunol. 2010;11:836-45. (FC)|9. Puga I, Cols M, Barra CM, He B, Cassis L, Gentile M, et al. B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen. Nat Immunol. 2012;13:170-80. (FC, IHC-FS)|10. Gieseke F, Mang P, Viebahn S, Sonntag I, Kruchen A, Erbacher A, et al. Siglec-7 tetramers characterize B-cell subpopulations and leukemic blasts. Eur J Immunol. 2012;42:2176-86. (FC)|11. Li FJ, Schreeder DM, Li R, Wu J, Davis RS. FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation. Eur J Immunol. 2013;43:2980-92. (FC)|12. Jiang A, Clark EA. Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis. J Immunol. 2001;166:6025-33. (Stim)|13. Rankin AL, Seth N, Keegan S, Andreyeva T, Cook TA, Edmonds J, et al. Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis. J Immunol. 2013;191:4540-50. (Stim)|14. Smith MJ, Packard TA, O'Neill SK, Dunand CJ, Huang M, Fitzgerald-Miller L, et al. Loss of anergic B cells in pre-diabetic and new onset T1D patients. Diabetes. 2014 Dec 18. pii: DB_131798. [Epub ahead of print]. (Stim)
USBio References
No references available
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