ADAM12

Clone Type

Monoclonal

Host

Mouse

Source

Human

Isotype

IgG3,k

Clone Number

1G3

Grade

Affinity Purified

Applications

E WB

Crossreactivity

Accession #

NM_003474, NP_003465

Shipping Temp

Blue Ice

Storage Temp

4°C Do Not Freeze

Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.

Applications

Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution

Optimal dilutions to be determined by the researcher.

AA Sequence

ETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQ

Storage and Stability

May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Immunogen

Partial recombinant protein corresponding to aa208-304 from ADAM12 with GST tag. MW of the GST tag alone is 26kD.

Form

Supplied as a liquid in PBS, pH 7.4.

Purity

Purified by Protein A affinity chromatography.

Specificity

Recognizes human ADAM12.

References

1. TM4SF3 promotes esophageal carcinoma metastasis via upregulating ADAM12m expression. Zhou Z, Ran YL, Hu H, Pan J, Li ZF, Chen LZ, Sun LC, Peng L, Zhao XL, Yu L, Sun LX, Yang ZH.Clin Exp Metastasis. 2008;25(5):537-48. Epub 2008 Mar 26.

USBio References

No references available

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122969 Mouse Anti-ADAM12 (Disintegrin and Metalloproteinase Domain-containing Protein 12, ADAM 12, Meltrin-alpha, MLTN, UNQ346/PRO545)

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Grade

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Crossreactivity

Accession #

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References

USBio References

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