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144495-ML550 Rabbit Anti-Erythropoietin (EPO) (MaxLight 550)

Specifications
References
Brand
MaxLight™
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P01588
Conjugate
MaxLight™550
Isotype
IgG
Grade
Affinity Purified
Applications
FLISA IHC WB
Crossreactivity
Hu
Gene ID
EPO
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze
Notes
Preservative Free
BSA Free

EPO, Erythropoietin, is an acidic glycoprotein hormone with a molecular mass of 34 kD. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow. This gene is mapped to 7q22.1. It is produced by interstitial fibroblasts in the kidney in close association with peritubular capillary and tubular epithelial cells. It is also produced in perisinusoidal Ito cells in the liver. While liver production predominates in the fetal and perinatal period, renal production is predominant during adulthood. As the prime regulator of red cell production, its major functions are to promote erythroid differentiation and to initiate hemoglobin synthesis. It also has other known biological functions. For example, erythropoietin plays an important role in the brain's response to neuronal injury.[1] EPO is also involved in the wound healing process.

Applications
Suitable for use in FLISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
Recombinant protein corresponding to human EPO at position M1-R166, expresed in E.coli.
Form
Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™550.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human EPO. No crossreactivity with other proteins.
References
1. Brines, M. et al., Proc. Nat. Acad. Sci. 97: 10526-10531, 2000. 2. Casals-Pascual, C., et al., Proc. Nat. Acad. Sci. 105: 2634-2639, 2008. 3. Celik, M., et al., Proc. Nat. Acad. Sci. 99: 2258-2263, 2002.
USBio References
No references available
Conjugates
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