Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein, BCL2 Associated X Protein omega, BCL2 Associated X Protein Transcript Variant delta2, BCL2L4

Recognizes a protein of 21kD, identified as the Bax protein. This MAb is highly specific to Bax and shows no cross-reaction with Bcl-2a or Bcl-X protein. Bcl-2 blocks cell death following a variety of stimuli. Bax has extensive amino acid homology with Bcl-2 and it homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.