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216119 Mouse Anti-ADAMTS4 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4)

Specifications
Clone Type
Monoclonal
Host
Mouse
Source
Human
Isotype
IgG2
Clone Number
14L23
Grade
Affinity Purified
Applications
N WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Applications
Suitable for use in Neutralization and Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1:500-1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Recombinant protein corresponding to human ADAMTS4
Form
Supplied as a lyophilized powder in PBS. Reconstitute with 200ul sterile PBS.
Purity
Purified by Protein G affinity chromatography from culture supernatant.
Specificity
Recognizes human ADAMTS4.
Conjugates
Pricing
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