Basic helix loop helix PAS protein MOP2, Basic-helix-loop-helix-PAS protein MOP2, bHLHe73, Class E basic helix-loop-helix protein 73, ECYT4, Endothelial PAS domain containing protein 1, Endothelial pas domain protein 1, Endothelial PAS domain-containing protein 1, EPAS 1, EPAS-1, EPAS1, EPAS1_HUMAN, HIF 1 alpha like factor, HIF 2 alpha, HIF-1-alpha-like factor, HIF-2-alpha, HIF1 alpha like factor, HIF2-alpha, HIF2A, HLF, Hypoxia inducible factor 2 alpha, Hypoxia inducible factor 2 alpha subunit, Hypoxia-inducible factor 2-alpha, Member of PAS protein 2, Member of pas superfamily 2, MOP 2, MOP2, PAS domain-containing protein 2, PASD2

Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumors. HIF2A is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF1A has been observed in varying subsets of tumor cells from various solid tumors. HIF2A is also a potent activator of the tie2 gene, which is known to be selectively expressed in endothelial cells.