PTPRB is a member of the protein tyrosine phosphatase (PTP) family. The family comprises at least 37 proteins characterized by a catalytic phosphatase domain of approximately 240aa and includes both transmembrane and cytosolic enzymes. PTP1B is a transmembrane PTP The PTPs have high substrate specificity for phosphotyrosyl proteins at the primary sequence level sharing little similarity with the protein serine phosphatases protein threonine phosphatases or the acid and alkaline phosphatases. PTP beta interacts with and regulates the tyrosine phosphorylation level of catenins which are critical in physiological and pathological events such as cell migration adhesion and transformation.
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