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349651 Mouse Anti-ACAT1 (Acetyl-CoA Acetyltransferase 1, ACAT, MAT, T2, THIL)

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Human
Isotype
IgG1,k
Clone Number
16C5
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_000010
Shipping Temp
Blue Ice
Storage Temp
-20°C

ACAT1 (acetyl-Coenzyme A acetyltransferase 1) is a 417aa protein. ACAT1 is a mitochondrial enzyme involved in the formation and degradation of ketone bodies and is necessary for the proper metabolic processing of isoleucine. ACAT1 and ACAT2 catalyze the formation of acetoacetyl-CoA from two acetyl-CoA molecules. These enzymes are also capable of the reverse reaction. Defects in ACAT1 are a cause of 3-ketothiolase deficiency. 3-ketothiolase deficiency is an inborn error of isoleucine catabolism characterized by intermittent ketoacidotic attacks associated with unconsciousness. Some patients die during an attack or are mentally retarded.

Applications
Suitable for use in ELISA, Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Hybridoma
FO myeloma cells with spleen cells from Balb/c mice.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Recombinant protein corresponding to aa34-427 from human ACAT1 expressed in E. coli.
Form
Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 10% glycerol.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes human ACAT1.
References
1. Antonenkov, V.D., et al. (2000) Eur J Biochem 267: 2981-2990 2. Korman, S.H. (2006) Mol Genet Metab 89: 289-299 3. Yamaguchi, S., et al. (1988) J Clin Invest 81(3): 813-817.
USBio References
No references available
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