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366830 Rabbit Anti-COPS7B, ID (COP9 Signalosome Complex Subunit 7b, SGN7b, Signalosome Subunit 7b, JAB1-containing Signalosome Subunit 7b, CSN7B)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9H9Q2
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Gene ID
64708
Gene #
COPS7B
Shipping Temp
Blue Ice
Storage Temp
-20°C

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to aa223-257 from the central region of human COPS7B, KLH conjugated. Species sequence homology: bovine
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes human COPS7B.
References
1. Ota T.,et al.Nat. Genet. 36:40-45(2004). 2. Hillier L.W.,et al.Nature 434:724-731 (2005). 3. Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. 4. Bech-Otschir D.,et al.EMBO J. 20:1630-1639 (2001). 5. Lyapina S.,et al.Science 292:1382-1385 (2001).
USBio References
No references available
Conjugates
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