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489720 Rabbit Anti-PTHLH (Parathyroid Hormone Related Protein)

Specifications
Clone Type
Polyclonal
Host
Rabbit
Source
Mouse
Swiss Prot
P22858
Isotype
IgG
Grade
Affinity Purified
Applications
IHC WB
Crossreactivity
Bo Ca Eq Gt Gp Hu Mo Rb Rt
Accession #
NP_032996
Gene ID
19227
Gene #
PTHLH
Shipping Temp
Blue Ice
Storage Temp
-20°C
PTH-like, Pthrp

Pthlh is a neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. It regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is required for skeletal homeostasis. It promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. It upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.

Applications
Suitable for use in Immunohistochemistry, Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to a region of mouse PTHLH.
Form
Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Purity
Purified by affinity chromatography.
Specificity
Recognizes mouse PTHLH. Species Crossreactivity: bovine, canine, goat, guinea pig, equine, human, rabbit, rat
Conjugates
Pricing
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