5 HT 1A, 5 HT receptor 1A, 5 HT1A, 5 HT1A receptor, 5 hydroxytryptamine (serotonin) receptor 1A, 5 hydroxytryptamine (serotonin) receptor 1A G protein coupled, 5 hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, 5-hydroxytryptamine receptor 1A, 5HT 1A, 5HT 1A receptor, 5HT receptor 1A, 5HT1a, 5HT1A_HUMAN, ADRB2RL1, ADRBRL1, G 21, G protein coupled receptor, G-21, Gpcr 18, Gpcr18, Guanine nucleotide binding regulatory protein-coupled receptor, Htr1a, PFMCD, Serotonin 1A receptor, Serotonin 5HT1A receptor, Serotonin receptor 1A
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Applications
Suitable for use in Western Blot, Immunofluorescence/Immunocytochemistry and ELISA. Other applications not tested.
Recommended Dilution
Western Blot: 1:500-1:2000, incubate membrane with diluted primary antibody in TBS, 5% milk, 0.1% Tween 20 at 4°C with gentle shaking, overnight. Immunofluorescence (IF-IC): 1:100-1:500 ELISA (peptide): 1:20,000-1:40,000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to human 5-HT-1A.
Form
Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes endogenous levels of human 5-HT-1A. Species Crossreactivity: mouse and rat
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