CAK, CD 167, CD167, CD167 antigen-like family member A, CD167a, Cell adhesion kinase, DDR 1, DDR, DDR1, DDR1_HUMAN, Discoidin domain receptor, Discoidin domain receptor tyrosine kinase 1, Discoidin receptor tyrosine kinase, Discoidin receptor tyrosine kinase isoform a, EDDR 1, EDDR1, Epithelial discoidin domain receptor 1, Epithelial discoidin domain-containing receptor 1, Epithelial specific receptor kinase, HGK2, Mammarian carcinoma kinase 10, Mammary carcinoma kinase 10, MCK-10, MCK10, NEP, Neuroepithelial tyrosine kinase, Neurotrophic tyrosine kinase receptor type 4, NTRK 4, NTRK4, OTTHUMP00000029343, OTTHUMP00000029344, OTTHUMP00000029345, OTTHUMP00000029346, OTTHUMP00000029347, OTTHUMP00000164863, OTTHUMP00000164867, OTTHUMP00000222080, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, PTK 3, PTK 3A protein tyrosine kinase 3A, PTK3, PTK3A, Receptor tyrosine kinase NEP, RTK 6, RTK6, TRK E, TRKE, Tyrosine kinase DDR, Tyrosine kinase receptor E, Tyrosine-protein kinase CAK

The discoidin domain receptors (DDRs) are receptor tyrosine kinases with a discoidin homology repeat in their extracellular domains, activated by binding to extracellular matrix collagens. So far, two mammalian DDRs have been identified: DDR1 and DDR2. They are widely expressed in human tissues and may have roles in smooth muscle cell-mediated collagen remodeling. Aberrant expression and signaling of DDRs have been implicated in human disease related to increased matrix degradation and remodeling such as cardiovascular disease, liver fibrosis and tumor invasion.