AAD10, ALL1 related gene, ALL1-related protein, ALR, CAGL114, Histone-lysine N-methyltransferase MLL2, KABUK1, Kabuki make up syndrome, Kabuki mental retardation syndrome, KMS, KMT2B, KMT2D, Lysine N methyltransferase 2D, Lysine N-methyltransferase 2B, MLL2, MLL2_HUMAN, MLL4, Myeloid/lymphoid or mixed lineage leukemia 2, Myeloid/lymphoid or mixed-lineage leukemia protein 2, TNRC21, Trinucleotide repeat containing 21
Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.
Applications
Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000-1:3000, incubate membrane with diluted antibody in TBS, 5% milk, 0.1% Tween20 at 4°C with gentle shaking, overnight. Immunohistochemistry: 1:50-200 ELISA (peptide): 1:20,000-1:40,000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to human MLL2. Species sequence homology: porcine (100%), bovine (100%), sheep (100%), rabbit (83%), canine (100%)
Form
Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes endogenous levels of total human MLL2.
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