12-O-tetradecanoylphorbol 13-acetate repressed protein 1, AI174028, C-X-C motif chemokine 12, Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1), Chemokine (C-X-C motif) ligand 12, Chemokine CXC motif ligand 12, cxcl12, hIRH, hSDF-1, Intercrine reduced in hepatomas, IRH, OTTHUMP00000019491, PBSF, Pre-B cell growth-stimulating factor, SCYB12, SDF 1, SDF-1, SDF-1-alpha(3-67), SDF-1a, SDF-1b, SDF1_HUMAN, SDF1A, SDF1B, Stromal cell-derived factor 1, Stromal cell-derived factor 1 delta, Stromal cell-derived factor 1 gamma, Stromal cell-derived factor 1a, Stromal cell-derived factor-1 alpha, Thymic lymphoma cell-stimulating factor, Tlsf, TLSF-a, TLSF-b, Tlsfa, Tlsfb, TPAR1

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase.