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A2295-01W8 Rabbit Anti-Angiotensin Converting Enzyme 2, ACE 2

Specifications
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9BYF1
Isotype
IgG
Grade
Affinity Purified
Applications
IHC WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

ACE2 is a carboxypeptidase which is expressed in a range of tissues including heart, kidney, testis and the gastrointestinal system. ACE2 is a homologue of ACE (Angiotensin-converting enzyme 1), although it has a distinct catalytic activity. ACE2 catalyzes the cleavage of active angiotensin II into angiotensin 1-7, which may counteract the effects of ACE by increasing vasodilatation. A recent discovery is that ACE2 serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus, functioning as a receptor for the SARS Spike protein.

Applications
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry (paraffin): requires antigen retrieval using heat treatment prior to staining of paraffin sections. Optimal dilution determined by the researcher.
Recommended Secondary Reagents
Sheep anti rabbit IgG: HRP
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to a sequence within the amino terminus of human ACE2.
Form
Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
Purity
Purified by affinity chromatography.
Specificity
Recognizes human Angiotensin-converting enzyme 2 (ACE2).
Conjugates
Pricing
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