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B0807-52 Rat Anti-BCMA (B Cell Maturation Protein)

Specifications
References
Clone Type
Monoclonal
Host
Rat
Source
Mouse
Swiss Prot
O88472
Isotype
IgG2a
Clone Number
6D163
Grade
Affinity Purified
Applications
FC IP WB
Crossreactivity
Mo
Shipping Temp
Blue Ice
Storage Temp
-20°C

BCMA is a member of the TNF receptor superfamily. It binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines. It plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB and JNK. The human BCMA gene codes for a 184aa type I transmembrane protein, which contains a 54aa extracellular domain, a 23aa transmembrane domain, and a 107aa extracellular domain.

Applications
Suitable for use in Immunoprecipitation, Flow Cytometry, Western Blot and Functional Applications. Other applications not tested.
Recommended Dilutions
Immunoprecipitation: 1:200 Flow Cytometry: 1:1000 Western Blot: 1:1000 Functional Application: Blocks binding of BAFF to mouse BCMA. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Recombinant protein corresponding to aa1-46 from mouse BCMA at the extracellular domain.
Form
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity
Purified by Protein G affinity chromatography from concentrated tissue culture supernatant.
Specificity
Recognizes mouse BCMA. Does not crossreact with human BCMA.
References
1. S. Shulga-Morskaya, et al.; J. Immunol. 173, 2331 (2004) 2.E. Castigli, et al.; J. Exp. Med. 201, 35 (2005) Abstract. 3. APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis: G. Hardenberg, et al.; J. Leukoc. Biol. 84, 380 (2008)
USBio References
No references available
Conjugates
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