CD18 is a 95kD protein, also known as integrin b2 subunit. It is expressed on all leukocytes. CD18, in association with integrin a chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and aXb2, respectively, and plays an important role in leukocytes adhesion. The CD18 integrin complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen. This antibody is able to block tumor cell metastasis and enhance cell adhesion.
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