The IL-2 receptor (IL-2R) exists in three alternative forms made up from the individual components of CD25, CD122, and CD132. CD25 represents the low affinity alpha chain of the IL-2R, a type I transmembrane glycoprotein containing two CCP domains. It is rich in O-linked carbohydrates and has a short cytoplasmic tail.14 CD25 is expressed on activated T cells, B cells, NK cells and monocytes of all mouse strains tested.2, 3, 15 Expression of CD25 on activated T lymphocytes is transitory and endogenously regulated.4 CD25 is expressed on precursor B cells in bone marrow. Its expression is initiated by functional rearrangement and expression of IgM heavy chain genes and is down-regulated when immature B cells mature and express IgD.5 It is expressed at a higher level on CD4+CD8+ thymocytes.5, 6 It is also expressed on cultured epidermal Langerhans cells.7 The biochemical features of murine CD25 have been characterized in detail.8-10. This antibody, used in combination with C2275-89A in culture, results in higher levels of inhibition of proliferation driven by IL-2 and generation of alloreactive CTL than either of these monoclonal antibodies alone. 2, 13
Product | Size | List | Your Price | Qty | Ext Price | ||||
---|---|---|---|---|---|---|---|---|---|
Subtotal: | Subtotal: | ||||||||
Subtotal: | Subtotal: | ||||||||
Total Coupon Savings: | Total Coupon Savings: | () | |||||||
Your cart is currently empty. | |||||||||
- Coupon Code |