CD36

Clone Type

Monoclonal

Host

Mouse

Source

Human

Conjugate

APC

Isotype

IgG2a,k

Clone Number

0.N.107 (185-1G2)

Grade

Affinity Purified

Applications

FC IF IHC

Crossreactivity

Shipping Temp

Blue Ice

Storage Temp

4°C Do Not Freeze

Notes

BSA Free

CD36 (also known as platelet glycoprotein IV, OKM5-antigen, or platelet glycoprotein IIIb) acts as a receptor for thrombospondin (TSP), collagen, falciparum malaria parasitized erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low density lipoprotein (LDL), and apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischaemia observed in sickle cell disease and cerebral malaria.

Applications

Suitable for use in Function Blocking, Flow Cytometry, Immunofluorescence and Immunohistochemistry. Not suitable for use in Western Blot. Other applications have not been tested.

Recommended Dilutions

Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher.

Positive Control: Tonsil

Storage and Stability

Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Note: Applications are based on unconjugated antibody.

Immunogen

Stimulated human leukocytes. Cellular Localization: Cell membrane

Form

Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).

Purity

Purified by Protein A affinity chromatography.

Specificity

Recognizes Human CD36 (MW: 88kD). Blocks adhesion of P. falciparum parasitized red blood cells to CD36. Strongly inhibits collagen-induced platelet aggregation.

References

1. Kishimoto, T., et al., eds. Leukocyte Typing VI, p636-643 and p1136-1137 (1997), Garland Publishing, Inc, New York and London. 2. Greenwalt, D.E., Ikeda, H.,Tandon, N.N., Jamieson, G.A.: Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine. Blood 80: 1105 (1992). 3. Savill, J., et al.: Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J. Clin. Invest. 90(4): 1513-1522 (1992). 4. Stomski, F.C., et. al., Experimental Cell Research 198(1): 85-92 (1992). 5. Biggs, B.A., et al., Journal of Experimental Medicine 171(6): 1883-1892 (1990).

USBio References

No references available

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C2388-15X-APC Mouse Anti-CD36 (gpIIIb, gpIV, Thrombospondin Receptor) (BSA & Azide Free) (APC)

Clone Type

Host

Source

Conjugate

Isotype

Clone Number

Grade

Applications

Crossreactivity

Shipping Temp

Storage Temp

Notes

References

USBio References

Conjugates

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