The CD98 molecule is a heterodimer made of a disulfide-linked glycosylated heavy chain of approximately 80-90kD and a non-glycosylated light chain. The heavy chain is a type II integral membrane protein containing a 50-81aa NH2-terminal cytoplasmic domain, a single transmembrane sequence, and a large extracellular domain. CD98 is detected on monocytes and activated cells.
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