CD104 is a 205kD type I transmembrane glycoprotein, known as integrin b4 chain or b4 integrin, that associates with integrin a6 (CD49f) forms a6/b4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells and a subset of pre-T cells. CD49f/CD104 is an adhesion receptor for laminins (especially laminin 5) and keratin filaments and is involved in the regulation of hemidesmosome formation and of cell proliferation and activation.
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